GLUTATHIONE PEROXIDASE 4 (GPX4) AND OBESITY INTERACT TO IMPACT TUMOR PROGRESSION AND TREATMENT RESPONSE IN TRIPLE NEGATIVE BREAST CANCER

Glutathione peroxidase 4 (GPX4) and obesity interact to impact tumor progression and treatment response in triple negative breast cancer

Abstract Introduction Triple-negative breast cancer (TNBC), which tends to be more advanced when diagnosed and more aggressive than other breast cancer subtypes, is accelerated by obesity.Hypertrophic adipocytes and cancer cells exhibit increased oxidative stress and altered redox homeostasis, influencing therapeutic outcomes.Enzymes implicated in

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